کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
231996 1427462 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calculation of solubility of methimazole, phenazopyridine and propranolol in supercritical carbon dioxide
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Calculation of solubility of methimazole, phenazopyridine and propranolol in supercritical carbon dioxide
چکیده انگلیسی

The calculation of solid-fluid equilibrium at high pressure is important in the modeling of separation of biomolecules from food and pharmaceutical products. In this study, three equations of state along with three mixing rules are used to calculate the solubility of methimazole, phenazopyridine and propranolol, as three representative drugs, in supercritical carbon dioxide. The equations of state are: Peng–Robinson (PR), Pazuki and others and a modified PR equation. Mixing rules are VdW 1, VdW 2 and Adachi–Sugie. It is shown that Pazuki equation along with VdW 2 mixing rule is more accurate than other equations. Interaction parameters for studied systems are obtained and the percentage of average absolute relative deviation (%AARD) in calculation is displayed. Also, we use Mendez-Santiago–Teja equation to check the consistency of experimental data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Supercritical Fluids - Volume 43, Issue 3, January 2008, Pages 390–397
نویسندگان
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