کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
232205 | 1427476 | 2006 | 7 صفحه PDF | دانلود رایگان |
Equilibrium data of the solubility of carbon dioxide in Precirol® ATO5, Compritol® 888 ATO and Gelucire® 43-01, three solid lipid carriers suitable for controlled/sustained delivery, were measured by a static analytical method for three different temperatures each, in a pressure range from 10 to 20 MPa. The influence of the presence of carbon dioxide in the melting point of the lipid matrices was also studied by a visual method for pressures up to 30 MPa. All the compounds studied presented a similar behaviour in the presence of carbon dioxide, showing a decrease in the melting points between 5 and 13 °C, whereas the solubility of carbon dioxide varies from 0.3 to 0.5 g/g of lipid compound. These results are of utmost importance to design supercritical fluid processes for particle formation at lower operating costs.
Journal: The Journal of Supercritical Fluids - Volume 39, Issue 1, November 2006, Pages 13–19