کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2401951 | 1102383 | 2007 | 9 صفحه PDF | دانلود رایگان |
SummaryEfforts to develop a new, more effective vaccine for tuberculosis have been hampered by a lack of understanding of what constitutes a protective memory immune response. While interferon γ production by CD4+ T cells after vaccination is commonly used as a surrogate of protective memory immunity, its use in this regard appears to have little predictive value. We argue that this is due to the different requirements for interferon γ-mediated protection in the primary response versus the memory recall response. In this review, we present evidence that suggests memory CD4+ T cells can protect against tuberculosis in the absence of interferon γ, and discuss potential mechanisms that may be involved such as IL-17 and regulatory T cells. A comprehensive understanding of the requirements for protective memory immunity to tuberculosis is essential for the development of an effective vaccine.
Journal: Tuberculosis - Volume 87, Issue 6, November 2007, Pages 465–473