کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402029 1102388 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis
چکیده انگلیسی

SummaryMycobacterium tuberculosis EthR is a repressor of ethA, a gene encoding a mono-oxygenase required for the activation of the prodrug ethionamide. Two EthR crystal structures have been reported recently, either in a ligand-bound (Frenois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V. Mol Cell 2004; 16: 301–7) or in a presumed apo conformation (Dover LG, Corsino PE, Daniels IR, Cocklin SL, Tatituri V, Besra GS, Futterer K. J Mol Biol 2004; 340: 1095–105). In order to infer the EthR induction mechanism, we have compared these structures. It appears that the two structures are in a conformation incompatible with repressor function, due to the presence in both proteins of fortuitous and structurally unrelated ligands. This observation paves the way to the design of specific drugs that could increase the sensitivity of M. tuberculosis to ethionamide.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 86, Issue 2, March 2006, Pages 110–114
نویسندگان
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