کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2428270 1106293 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of peripheral blood lymphocyte subsets in family-owned dogs naturally infected by Ehrlichia canis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Evaluation of peripheral blood lymphocyte subsets in family-owned dogs naturally infected by Ehrlichia canis
چکیده انگلیسی

Previous research suggested that clinical manifestations, histopathological lesions, and even infection maintenance in the course of canine monocytic ehrlichiosis (CME) are directly related to the immune response developed by the host. In the present study, blood lymphocyte subsets were analyzed by multiparametric flow cytometry in 37 dogs with naturally occurring CME and 47 healthy dogs used as controls. T, T helper (Th), T cytotoxic (Tc), B, non-T, non-B lymphocytes and those that express MHC class II were characterized in every dog. Animals with CME showed higher relative values of T and Tc cells and a higher absolute number of Tc cells in peripheral blood. The percentage of Th cells and the absolute and relative values of B cells were higher in healthy animals than in CME-affected dogs. The significance of these changes on the pathogenesis of natural Ehrlichia canis infection in dogs needs further evaluation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 35, Issue 4, July 2012, Pages 391–396
نویسندگان
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