کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2428930 1106462 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tracheal and bronchial polymeric immunoglobulin secretory immune system (PISIS) development in a porcine model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Tracheal and bronchial polymeric immunoglobulin secretory immune system (PISIS) development in a porcine model
چکیده انگلیسی


• PISIS is composed of JC-pIg producing cells, mucosal epithelial pIgR and secretory Abs.
• The secretory component (pIgR) seems to be the only PISIS element in the newborn.
• During the first two days of life, maternal colostrum Igs appears at mucosal sites.
• Relevant concentration of IgG was also detected at respiratory secretions.
• Complete, structured PISIS was found at the pig's respiratory tract after weaning.

Polymeric immunoglobulins (pIgs) mucosal secretion is mediated by the pIg secretory immune system (PISIS), which is composed of J-chain (JC) and antibody (IgM/IgA) producing cells (JC-AbPC), pIg receptor (pIgR) epithelial cell expression and the efficient release of secretory Igs (SIgs) to the mucosal lumen. A poor development or disturbances in this system may cause higher infection susceptibility, as observed in young and elderly people. In spite of this system's importance, few detailed studies regarding its development have been described in the lower respiratory tract of humans. Because the porcine model has been reported as an option for translational medicine to humans, we studied the tracheal and bronchial PISIS development in healthy, non-vaccinated, SPF, miniature Vietnamese pigs from birth to adulthood using immunohistochemistry and ELISAs. Our results demonstrated that pIgR was present at birth, and its expression increased with age. In contrast, JC-AbPC were low in neonatal pigs; however, colostrum was a source of IgM, SIgA, total IgA and IgG in respiratory secretions (trachea and bronchoalveolar lavages, nasal secretion and saliva) in piglets. JC-AbPC steadily increased in post-weaned, young and adult pigs, correlating with considerable increases in secretory and total Igs in the trachea and bronchi. These data suggest a compensatory role of maternal Igs at the respiratory mucosa in the absence of a structured PISIS before weaning. Furthermore, monomeric Igs (IgG and IgA) may also play an important role in respiratory protection and deserves a more thorough study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 53, Issue 2, December 2015, Pages 271–282
نویسندگان
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