کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2429291 1106488 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Innate immune responses of salmonid fish to viral infections
ترجمه فارسی عنوان
واکنش های ایمنی فراگیر ماهی آزاد به عفونت های ویروسی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


• The type I Interferon is induced in salmonids following infection with all known types of viruses.
• Dendritic cells and natural killer cell markers have been identified in salmonids and their involvement in viral infection confirmed.
• Viruses have evolved immune evasion mechanisms.

Viruses are the most serious pathogenic threat to the production of the main aquacultured salmonid species the rainbow trout Oncorhynchus mykiss and the Atlantic salmon Salmo salar. The viral diseases Infectious Pancreatic Necrosis (IPN), Pancreatic Disease (PD), Infectious Haemorrhagic Necrosis (IHN), Viral Haemorrhagic Septicaemia (VHS), and Infectious Salmon Anaemia (ISA) cause massive economic losses to the global salmonid aquaculture industry every year. To date, no solution exists to treat livestock affected by a viral disease and only a small number of efficient vaccines are available to prevent infection. As a consequence, understanding the host immune response against viruses in these fish species is critical to develop prophylactic and preventive control measures. The innate immune response represents an important part of the host defence mechanism preventing viral replication after infection. It is a fast acting response designed to inhibit virus propagation immediately within the host, allowing for the adaptive specific immunity to develop. It has cellular and humoral components which act in synergy. This review will cover inflammation responses, the cell types involved, apoptosis, antimicrobial peptides. Particular attention will be given to the type I interferon system as the major player in the innate antiviral defence mechanism of salmonids. Viral evasion strategies will also be discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 43, Issue 2, April 2014, Pages 160–173
نویسندگان
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