کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2429307 1106489 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Caudal is a negative regulator of the Anopheles IMD Pathway that controls resistance to Plasmodium falciparum infection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Caudal is a negative regulator of the Anopheles IMD Pathway that controls resistance to Plasmodium falciparum infection
چکیده انگلیسی

Malaria parasite transmission depends upon the successful development of Plasmodium in its Anopheles mosquito vector. The mosquito’s innate immune system constitutes a major bottleneck for parasite population growth. We show here that in Anopheles gambiae, the midgut-specific transcription factor Caudal acts as a negative regulator in the Imd pathway-mediated immune response against the human malaria parasite Plasmodium falciparum. Caudal also modulates the mosquito midgut bacterial flora. RNAi-mediated silencing of Caudal enhanced the mosquito’s resistance to bacterial infections and increased the transcriptional abundance of key immune effector genes. Interestingly, Caudal’s silencing resulted in an increased lifespan of the mosquito, while it impaired reproductive fitness with respect to egg laying and hatching.


► Caudal-silenced mosquitoes have enhanced resistance to Plasmodium falciparum infection.
► Caudal regulates the mosquito midgut microbiota.
► Silencing of Caudal enhanced resistance to systemic bacterial infections.
► Caudal-silenced mosquitoes live longer but have impaired fecundity and fertility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 39, Issue 4, April 2013, Pages 323–332
نویسندگان
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