کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2429572 | 1553581 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas](/preview/png/2429572.png)
Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues.
► Oyster antimicrobials display different expression profiles in hemocytes and tissues.
► Hemocytes drive antimicrobials to tissues contributing with their colocalization.
► Oyster antimicrobials show synergistic activity in vitro.
► Synergy might compensate the low concentration of antimicrobials in oyster tissues.
Journal: Developmental & Comparative Immunology - Volume 37, Issues 3–4, July 2012, Pages 363–370