کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2440207 | 1553847 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short Communication: Duplication in the 5â²-Flanking Region of the β-Lactoglobulin Gene is Linked to the BLG A Allele
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Short Communication: Duplication in the 5â²-Flanking Region of the β-Lactoglobulin Gene is Linked to the BLG A Allele Short Communication: Duplication in the 5â²-Flanking Region of the β-Lactoglobulin Gene is Linked to the BLG A Allele](/preview/png/2440207.png)
چکیده انگلیسی
β-Lactoglobulin (β-LG) is the major whey protein in the milk of cows and other ruminants. It is well established that the predominant genetic variants β-LG A and B are differentially expressed. Extensive investigation of the genetic variation in the promoter region of the BLG gene revealed the existence of specific haplotypes associated with the A and B variants. However, the genetic basis for the differentially expressed BLG A and B alleles is still elusive. In this study additional genetic variation further upstream in the 5â²-flanking region of the BLG gene was identified, including 6 single nucleotide substitutions, a single nucleotide deletion, and a 7-bp duplication. Comparison of DNA sequences showed that the investigated 5â²-flanking region is highly conserved between ruminants, and the duplication g.-1885_-1879dupCTCTCGC and the substitution g.-1888A>G are only found in the BLG A and D alleles in cattle. The cytosine at position g.-1957 and the thymines at positions g.-2008 and g.-2049 are only found in BLG B alleles of cattle. It is suggested that the described genetic variability contributes to the differential allelic expression of the BLG gene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dairy Science - Volume 90, Issue 12, December 2007, Pages 5780-5783
Journal: Journal of Dairy Science - Volume 90, Issue 12, December 2007, Pages 5780-5783
نویسندگان
M.H. Braunschweig,