کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2454715 1554308 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
(+)-Catechin inhibition of transmissible gastroenteritis coronavirus in swine testicular cells is involved its antioxidation
ترجمه فارسی عنوان
(+) - مهار کورتونی از گاستروانتریت کبدی پروتئینی در سلول های بیضه خوک شامل آنتی اکسید شدن آن می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


• (+)-Catechin has anti-TGEV effect.
• Anti-TGEV effect was working after TGEV infection.
• (+)-Catechin could relieve CPE caused by TGEV in ST cells.
• TGEV proliferation was decreased after (+)-catechin incubation.
• Antioxidation of (+)-catechin is related to its antiviral effect.

ABSTRACTTransmissible gastroenteritis virus (TGEV) causes transmissible gastroenteritis (TGE), especially in newborn piglets, which severely threatens the worldwide pig industry. In this study, (+)-catechin was evaluated for its antiviral effect against TGEV in vitro. Viability assays revealed that (+)-catechin treatment exerted a dose-dependent rescue effect in TGEV-infected ST cells, and this result was only obtained with the post-treatment application of (+)-catechin. The viral yields in (+)-catechin-treated cultures were reduced by almost three log10 units. Quantitative real-time PCR analysis of the TGEV genome revealed that TGEV RNA replication was restricted after (+)-catechin treatment. Intracellular reactive oxygen species (ROS) detection showed that (+)-catechin alleviated ROS conditions induced by TGEV infection. Our results showed that (+)-catechin exerts an inhibitory effect on TGEV proliferation in vitro and is involved its antioxidation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 103, December 2015, Pages 28–33
نویسندگان
, , , , , , , ,