کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2456261 1110534 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced PKCα expression in pulmonary arterioles of broiler chickens is associated with early feed restriction
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Reduced PKCα expression in pulmonary arterioles of broiler chickens is associated with early feed restriction
چکیده انگلیسی

ObjectiveThe present study was conducted to investigate the effect of early feed restriction on protein kinase Cα (PKCα) expression in pulmonary arterioles, which has been revealed to promote pulmonary vascular remodeling in pulmonary hypertensive broilers.MethodsA total of 270 day-old mixed sex commercial broilers were randomly distributed to a normal temperature control group (NT), a low temperature control group (LT) and a low temperature plus feed restriction group (LR). The PHS incidence, the right/total ventricular weight ratio (RV/TV), the vessel wall area/vessel total area ratio (WA/TA), the mean media thickness in pulmonary arterioles (mMTPA) and the expression of PKCα in the pulmonary arterioles were measured weekly.ResultsLow temperature treatment significantly increased the PHS mortality. The RV/TV, WA/TA and mMTPA values of group LT were significantly elevated compared with those of group NT on d 35 and 42. The LT chickens had increased PKCα expression compared with their NT counterparts on d 28 and afterwards. Feed restriction reduced the PHS mortality, RV/TV, WA/TA and mMTPA in cold-exposed broilers. The LR chickens had much lower PKCα expression in pulmonary arterioles than the LT chickens.ConclusionEarly time feed restriction inhibited pulmonary vascular remodeling in broilers, which might be partly attributed to reduced PKCα expression in pulmonary arterioles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 84, Issue 3, June 2008, Pages 434–439
نویسندگان
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