کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461454 1555021 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative study of the biochemical properties of proteasomes in domestic animals
ترجمه فارسی عنوان
بررسی مقایسه ای خواص بیوشیمی پروتئازوم در حیوانات خانگی
کلمات کلیدی
پروتئازوم، ایمونو پروتئازوم، پروتئولیز، مهار کننده های پروتئازوم، حیوانات اهلی، فعالیت های پپتیداز پروتئازومی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

Information on the biochemical properties of proteasomes is lacking or, at best, only fragmentary for most species of veterinary interest. Moreover, direct comparison of the limited data available on the enzymatic features of proteasomes in domestic animals is rendered difficult due to the heterogeneity of the experimental settings used. This represents a clear drawback in veterinary research, given the crucial involvement of proteasomes in control of several physiological and pathological processes. We performed the first comparative analysis of key biochemical properties of proteasomes obtained from 8 different domestic mammals. Specifically, we investigated the three main peptidase activities of constitutive and immunoproteasomes in parallel and systematically checked the sensitivity of the chymotryptic site to three of the most potent and selective inhibitors available. Overall, there was substantial similarity in the enzymatic features of proteasomes among the species examined, although some interesting species-specific features were observed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 166, Issues 1–2, 15 July 2015, Pages 43–49
نویسندگان
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