کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2472137 | 1555785 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus](/preview/png/2472137.png)
چکیده انگلیسی
Insect vectors of disease have the capacity to respond to, and prevent further development of, parasites and pathogens using a response known as melanotic encapsulation. The naturally-occurring Armigeres subalbatus-Brugia spp. system provides an excellent way to investigate melanotic encapsulation and immune recognition in a mosquito host, because Brugia malayi microfilariae (mf) acquired via a blood meal are rapidly melanized in the body cavity of Ar. subalbatus, but Brugia pahangi mf evade or suppress the immune response and develop normally into infective stage larvae. Previous studies have suggested that B. pahangi mf are changed in some manner in the process of exiting the mosquito gut, thereby facilitating escape from, or suppression of, the melanotic encapsulation response. By inoculating mosquitoes with parasites, thus circumventing the midgut, we show that â¼88% of B. pahangi mf escape the melanotic encapsulation response while approximately 90% of inoculated B. malayi mf are melanized. Methods to isolate parasites for this procedure are described. These results mimic those observed in Ar. subalbatus against Brugia spp. mf that are ingested following blood feeding, and demonstrate that midgut penetration is not required for B. pahangi mf to avoid the melanotic encapsulation response of Ar. subalbatus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 144, Issues 3â4, 31 March 2007, Pages 371-374
Journal: Veterinary Parasitology - Volume 144, Issues 3â4, 31 March 2007, Pages 371-374
نویسندگان
Brenda T. Beerntsen, Lyric C. Bartholomay, Roy J. Lowery,