Inclusion of chrysin in β-cyclodextrin and its biological activities

Chrysin is a plant flavone that possesses some significant biological activities. β-Cyclodextrin (β-CD) due to its property of encapsulating molecules that are hydrophobic in nature is widely applied as drug delivery vehicle. The paper presents the preparation, characterization and properties of chrysin-β-cyclodextrin inclusion complex. The stoichiometry of the inclusion complex has been established to be 1:3 (chrysin to β-cyclodextrin), with the inclusion rate of 90.5 ± 2.63 at 55 °C. The process of inclusion not only increased the solubility of chrysin but also its antioxidant potential, antimicrobial activity and anti-tumor activity.

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