کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493214 1556634 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of ERK signaling in activity-dependent modifications of histone proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Role of ERK signaling in activity-dependent modifications of histone proteins
چکیده انگلیسی


• Activity-dependent ERK/MAPK pathway regulates both cytoplasmic and nuclear targets.
• H3 phospho-acetylation is the best studied histone modification regulated by ERK.
• H3S10 phosphorylation may promote additional histone and chromatin modifications.
• H3 phosphorylation is induced by a set of stimuli in selected brain regions.

It is well-established that neuronal intracellular signaling governed by the extracellular signal-regulated kinase (ERK/MAPK) plays a crucial role in long-term adaptive changes that occur during cognitive processes. ERK is a downstream component of a conserved signaling module that is activated by the serine/threonine kinase, Raf, which activates the MAPK/ERK kinase (MEK)1/2 protein kinases, which, in turn, activate ERK1/2. This signaling pathway has been reported to be activated in numerous physiological conditions due to a variety of stimuli, ranging from the activation of ionotropic glutamatergic receptors to metabotropic dopaminergic receptors and neurotrophin receptors. Interestingly, activated ERK can have early and late downstream effects at both the nuclear and synaptic levels. Locally, ERK signaling results in transient changes in the efficacy of synaptic transmission by modifying both pre- and post-synaptic targets. Once translocated into the nucleus, ERK signaling may control transcription by targeting several different regulators of gene expression such as transcription factors and histone proteins. ERK function is considered fundamental in processes such as long-term memory storage and drug addiction, by means of its role in activity-dependent epigenetic modifications that occur in the brain. In this review, we summarize the current understanding of ERK action in the neuroepigenetic processes underlying physiological responses, cognitive processes and drug addiction.This article is part of the Special Issue entitled ‘Neuroepigenetic Disorders’.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 80, May 2014, Pages 34–44
نویسندگان
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