کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493488 1556645 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The involvement of Reelin in neurodevelopmental disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The involvement of Reelin in neurodevelopmental disorders
چکیده انگلیسی

Reelin is a glycoprotein that serves important roles both during development (regulation of neuronal migration and brain lamination) and in adulthood (maintenance of synaptic function). A number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder, major depression, Alzheimer's disease and lissencephaly share a common feature of abnormal Reelin expression in the brain. Altered Reelin expression has been hypothesized to impair neuronal connectivity and synaptic plasticity, leading ultimately to the cognitive deficits present in these disorders. The mechanisms for abnormal Reelin expression in some of these disorders are currently unknown although possible explanations include early developmental insults, mutations, hypermethylation of the promoter for the Reelin gene (RELN), miRNA silencing of Reelin mRNA, FMRP underexpression and Reelin processing abnormalities. Increasing Reelin expression through pharmacological therapies may help ameliorate symptoms resulting from Reelin deficits.This article is part of the Special Issue entitled ‘Neurodevelopmental Disorders’.


► Reelin plays important roles in neuronal migration and brain development.
► Reelin is an important modulator of synaptic function.
► Reelin expression is altered in disorders such as schizophrenia and autism.
► Reelin is an important potential therapeutic target.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 68, May 2013, Pages 122–135
نویسندگان
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