کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493578 1556650 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
چکیده انگلیسی

Oxidative stress may be involved in the pathophysiology of schizophrenia. No double-blind study has compared the effects of typical and atypical antipsychotics on both antioxidant enzyme activity and nitric oxide (NO) levels in schizophrenic patients. Seventy-eight inpatients with chronic schizophrenia were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Blood superoxide dismutase (SOD) and plasma NO levels were measured in patients and 30 normal controls. Our results showed that following a 2-week washout period, levels of SOD and NO were significantly increased in patients with schizophrenia compared to normal controls. Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels in schizophrenia, but neither medication reduced the elevated plasma NO levels in schizophrenia. Low blood SOD levels at baseline predicted greater symptom improvement during treatment, and greater change in SOD was correlated with greater symptom improvement. These results suggest that both typical and atypical antipsychotic drugs may at least partially normalize abnormal free radical metabolism in schizophrenia, and some free radical parameters at baseline may predict antipsychotic responses of schizophrenic patients.


► 78 Patients were treated for 12-weeks with risperidone or haloperidol.
► Blood SOD and plasma NO levels were measured in patients and 30 normal controls.
► SOD and NO were significantly increased in patients with schizophrenia.
► Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels.
► Neither medication reduced the elevated plasma NO levels in schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 62, Issues 5–6, April 2012, Pages 1928–1934
نویسندگان
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