کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493832 1115530 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: Implications for studying addiction-related plasticity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: Implications for studying addiction-related plasticity
چکیده انگلیسی

Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of conventional forms of stress. We find an enhancement of excitatory synaptic strength in the NAc shell one day after exposure to a novel environment for 60 min – an effect not observed in NAc core. This effect disappeared following repeated exposure to the same environment, but then reappeared if mice are returned to the same environment 10–14 days later. There were no interactions between the effects of environmental novelty and a single exposure to cocaine (15 mg/kg), with no effect of the latter on synaptic strength in NAc shell. These results have important implications for designing studies of NAc synapses in the context of behavioral analysis, and expand our understanding of how different forms of stress modify NAc synaptic function.This article is part of a Special Issue entitled ‘Synaptic Plasticity and Addiction’.


► Exposure to a novel environment alters synaptic function in nucleus accumbens shell.
► Conventional forms of stressful experience cause similar synaptic changes.
► This effect is no longer observed after repeated exposure to the same context.
► The synaptic impact of the same context is renewed 10–14 days after repeated exposure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 61, Issue 7, December 2011, Pages 1152–1159
نویسندگان
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