کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493838 1115531 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Feeding and reward: Ontogenetic changes in an animal model of obesity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Feeding and reward: Ontogenetic changes in an animal model of obesity
چکیده انگلیسی

Given that food is a natural reinforcement, deficits in the reward system can lead to disordered eating behavior, inducing or worsening an already existing pre-obese phenotype. In order to evaluate developmental, food-reward-related measures we used the OLETF rat, an animal model of early-onset overeating-induced obesity, and a natural CCK-1 receptor knockout. Dopamine-like-receptor type 1 (D1R) and D2R levels were examined in a reward-related brain area (Nac shell) and sucrose preference was assessed at selected time points from weaning to adulthood (postnatal day [PND]90). In addition, a group of OLETF was pair fed (PF) to the amount of food consumed by same-age LETO controls (from weaning to PND 90) to examine the contribution of overweight to the alteration in DR expression. In addition, we examined food “craving”-like behavior by analyzing microstructural patterns of licking a palatable liquid diet. OLETF rats expressed significantly lower D2R levels than LETO controls only on PND 90. In PF OLETF, weight and D2R levels were normalized. In addition, OLETF presented exaggerated preference for the high sucrose concentration. After 30-day abstinence, OLETF rats presented significant increased initial rate of licking, suggesting food “craving”. Thus, adult OLETF rats demonstrated altered D2R signaling similar to drug-induced sensitization, suggesting a link with their avidity for sucrose and their abnormal craving response. However, the current findings of a late deficit appearance and the novel PF results suggest that deficits in the motivation/regulatory systems of the OLETF rat are a developing process (at least from weaning and on) depending on the overeating and obese phenotype of the rats and not only on the CCK mutation.


► We studied feeding & reward in OLETF rats, an animal model of obesity.
► OLETF presented exaggerated preference for high sucrose concentration.
► After 30-day preferred diet abstinence, OLETF showed food “craving”-like behavior.
► OLETF rats expressed lower D2R levels than controls only in adulthood.
► Diet-restriction normalized OLETF weight & D2R levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 62, Issue 8, June 2012, Pages 2447–2454
نویسندگان
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