Acidic pH facilitates peripheral αβmeATP-mediated nociception in rats: Differential roles of P2X, P2Y, ASIC and TRPV1 receptors in ATP-induced mechanical allodynia and thermal hyperalgesia

►αβmeATP-evoked mechanical allodynia was potentiated under pH 4.0 condition. ►αβmeATP (100 nmol) diluted in pH 4.0 saline newly developed thermal hyperalgesia. ►Acidic pH 4.0 saline facilitates mechanical allodynia via P2X receptor and ASICs. ►P2Y1 receptor and TRPV1 mediate thermal hyperalgesia under acidic pH 4.0 condition.