کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494742 1115578 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebral ischemia: Models, methods and outcomes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Cerebral ischemia: Models, methods and outcomes
چکیده انگلیسی

Experimental research into brain ischemia contributes substantially to the understanding of ischemic injury mechanisms but suffers from its limited relevance for clinical treatment startegies. One of the reasons is the use of experimental models and methods that do not or only partially replicate the pathophysiology of naturally occurring brain ischemia. To facilitate the understanding and interpretation of experimental data, the most widely used experimental models and analytical methods of brain ischemia are reviewed. Particular emphasis is given to the pathophysiological particularities of the various ischemia models, the application of imaging methods for the reliable differentiation between infarct core, penumbra, benign oligemia and normal tissue, as well as to the final outcome of experimental interventions. Based on this analysis, recommendations are given to improve the translational power of brain ischemia-related experimental research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 55, Issue 3, September 2008, Pages 257–270
نویسندگان
,