کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2494864 | 1115583 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine](/preview/png/2494864.png)
چکیده انگلیسی
Long-term caffeine intake has been reported to decrease the susceptibility to convulsants in mice. Occurrence of seizures following long-term oral administration of caffeine (0.3Â g/l) was investigated using adenosine A2A receptor knockout (A2AR KO) and control (A2AR WT) mice. Clonic seizures induced by acute pentylenetetrazol (PTZ, 50Â mg/kg i.p.) were significantly attenuated in adenosine A2AR KO mice drinking only water and reduced by a 14-day caffeine treatment in adenosine A2AR WT mice. In addition we showed a protecting effect of a 21-day caffeine treatment in A2AR WT mice against kindled seizures induced by PTZ in an increasing dose schedule. Summing up, these protective effects against PTZ-induced seizures occurring when adenosine A2AR is absent or chronically blocked by a relevant dose of caffeine may be related to a decreased neuronal excitability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 55, Issue 1, July 2008, Pages 35-40
Journal: Neuropharmacology - Volume 55, Issue 1, July 2008, Pages 35-40
نویسندگان
Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois,