کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494888 1115584 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma
چکیده انگلیسی

Free radical and calcium buffering mechanisms are implicated in cochlear cell damage that has been induced by sound trauma. Thus in this study we evaluated the therapeutic effect of a novel dual inhibitor of calpains and of lipid peroxidation (BN 82270) on the permanent hearing and hair cell loss induced by sound trauma. Perfusion of BN 82270 into the scala tympani of the guinea pig cochlea prevented the formation of calpain-cleaved fodrin, translocation of cytochrome c, DNA fragmentation and hair cell degeneration caused by sound trauma. This was confirmed by functional tests in vivo, showing a clear dose-dependent reduction of permanent hearing loss (ED50 = 4.07 μM) with almost complete protection at 100 μM. Furthermore, BN82270 still remained effective even when applied onto the round window membrane after sound trauma had occurred, within a therapeutic window of 24 h. This indicates that BN 82270 may be of potential therapeutic value in treating the cochlea after sound trauma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 52, Issue 6, May 2007, Pages 1426–1437
نویسندگان
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