کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2496835 | 1556701 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibition of cholinesterase by essential oil from food plant Inhibition of cholinesterase by essential oil from food plant](/preview/png/2496835.png)
Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's colorimetric method. The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C. aurantifolia leaf oil revealed in this study has an IC50 value on acetylcholinesterase and butyrylcholinesterase of 139 ± 35 and 42 ± 5 μg/ml, respectively. GC/MS analysis revealed that the major constituents of C. aurantifolia leaf oil are monoterpenoids including limonene, l-camphor, citronellol, o-cymene and 1,8-cineole.
Journal: Phytomedicine - Volume 19, Issues 8–9, 15 June 2012, Pages 836–839