کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507533 1117492 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of doxorubicin in pharmaceutical preparation and rat plasma with luminol-K3Fe(CN)6 chemiluminescence system
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Determination of doxorubicin in pharmaceutical preparation and rat plasma with luminol-K3Fe(CN)6 chemiluminescence system
چکیده انگلیسی

A novel and rapid flow injection chemiluminescence (FI-CL) method was established for the determination of doxorubicin, which was based on the phenomenon that CL intensity of the reaction between K3Fe(CN)6 and luminol in alkaline solution could be strongly enhanced by doxorubicin. Under optimum conditions, the relative CL intensity of the system was linear with the concentration of doxorubicin in the range from 2.0 × 10−9 g/mL to 5.0 × 10−7 g/mL with a correlation coefficient of 0.9993 (n = 9). The detection limit (3σ) was 4.25 × 10−10 g/mL, and the relative standard deviation (RSD) for 1.0 × 10−7 g/mL doxorubicin (n = 11) was 0.33%. The method was applied to the determination of doxorubicin in pharmaceutical preparation and rat plasma, and the percentage recovery of doxorubicin in rat plasma was between 89.8% and 102.2%. The possible CL mechanism was also discussed briefly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food and Drug Analysis - Volume 21, Issue 3, September 2013, Pages 279–285
نویسندگان
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