کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2530874 1558895 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipid droplets in activated mast cells – a significant source of triglyceride-derived arachidonic acid for eicosanoid production
ترجمه فارسی عنوان
قطرات لیپید در سلول های مشت فعال یک منبع مهم از اسید آراکیدونیک ترایکلسیرید برای تولید ایکوسانوئید است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Mast cells are potent effectors of immune reactions and key players in various inflammatory diseases such as atherosclerosis, asthma, and rheumatoid arthritis. The cellular defense response of mast cells represents a unique and powerful system, where external signals can trigger cell activation resulting in a stimulus-specific and highly coordinated release of a plethora of bioactive mediators. The arsenal of mediators encompasses preformed molecules stored in cytoplasmic secretory granules, as well as newly synthesized proteinaceous and lipid mediators. The release of mediators occurs in strict chronological order and requires proper coordination between the endomembrane system and various enzymatic machineries. For the generation of lipid mediators, cytoplasmic lipid droplets have been shown to function as a major intracellular pool of arachidonic acid, the precursor for eicosanoid biosynthesis. Recent studies have revealed that not only phospholipids in mast cell membranes, but also triglycerides in mast cell lipid droplets are a substrate source for eicosanoid formation. The present review summarizes current knowledge about mast cell lipid droplet biology, and discusses expansions and challenges of traditional mechanistic models for eicosanoid production.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 785, 15 August 2016, Pages 59–69
نویسندگان
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