کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534231 1559080 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Piroxicam accelerates development of colitis in T-cell receptor α chain-deficient mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Piroxicam accelerates development of colitis in T-cell receptor α chain-deficient mice
چکیده انگلیسی

T-cell receptor α chain (TCR·α)-deficient mice spontaneously develop colitis that resembles human ulcerative colitis; however, the incidence varies among individuals and takes place lately in the life. We have demonstrated that piroxicam induces colitis in non-colitic TCR·α-deficient mice, but not wild-type mice, within 14 days. The histological features and cytokine profiles were similar to those seen in spontaneous colitis in TCR·α-deficient mice. Dexamethasone prevented piroxicam-induced colitis concurrent with the suppression of interleukin (IL)-1β, IL-17, tumor necrosis factor α and interferon γ. This modified model of colitis could be useful for the evaluation of potential therapeutics for ulcerative colitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 615, Issues 1–3, 1 August 2009, Pages 241–245
نویسندگان
, , ,