کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2536368 | 1559152 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies](/preview/png/2536368.png)
The contribution of the endocannabinoid system to dopamine-mediated disorganized behavior in schizophrenia is discussed. We used a model of concurrent stimulation of dopamine D1 and D2 receptors to evaluate the role of this system in dopamine-mediated stereotypies measured in a hole-board test. Pretreatment with the cannabinoid CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A; 1 mg/kg) potentiated stereotyped behavior induced by coadministration of the dopamine D1 receptor agonist SKF 38393 (0.05, 0.1 and 1 mg/kg) and the dopamine D2 receptor agonist quinpirole (0.25 mg/kg). Thus, the endocannabinoid system acts as a brake for abnormal behavior associated with dopaminergic overactivation.
Journal: European Journal of Pharmacology - Volume 559, Issues 2–3, 22 March 2007, Pages 180–183