کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538279 1559643 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae)
چکیده انگلیسی

Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3H)-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds (1–4) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 102, April 2015, Pages 35–40
نویسندگان
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