کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538457 | 1559646 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator](/preview/png/2538457.png)
In a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a petroleum ether extract (100 μg/mL) of the resin of Boswellia thurifera (Burseraceae) potentiated GABA-induced chloride currents (IGABA) through receptors of the subtype α1β2γ2s by 319.8% ± 79.8%. With the aid of HPLC-based activity profiling, three known terpenoids, dehydroabietic acid (1), incensole (2), and AKBA (3), were identified in the active fractions of the extract. Structure elucidation was achieved by means of HR-MS and microprobe 1D/2D NMR spectroscopy. Compound 1 induced significant receptor modulation in the oocyte assay, with a maximal potentiation of IGABA of 397.5% ± 34.0%, and EC50 of 8.7 μM ± 1.3 μM. This is the first report of dehydroabietic acid as a positive GABAA receptor modulator.
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Journal: Fitoterapia - Volume 99, December 2014, Pages 28–34