New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa

Three new quinolone alkaloids, 1-methyl-2-[7-hydroxy-(E)-9-tridecenyl]-4(1H)-quinolone (1), 1-methyl-2-[(Z)-4-nonenyl]-4(1H)-quinolone (2), 1-methyl-2-[(1E,5Z)-1,5-undecadienyl]-4(1H)-quinolone (3) and one new natural product, 1-methyl-2-[(E)-1-undecenyl]-4(1H)-quinolone (4), were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds (5–17). In addition, one new artificial product, 1-methyl-2-[7-carbonyl-(E)-9-tridecenyl]-4(1H)-quinolone (1A) was also obtained. The structures of these compounds were determined by spectroscopic analyses. The cytotoxic activities of all of the compounds against the human cancer cell lines HL-60, N-87, H-460, and Hep G2 cells were evaluated by MTT assay. The results showed that these alkaloids inhibited cell proliferation with IC50 values between 14 μM and 22 μM.

Three new quinolone alkaloids (1–3) and one new natural product (4) were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds. In addition, one new artificial product (1A) was also obtained. All of these compounds were evaluated for their cytotoxic activities against the human cancer cell lines HL-60, N-87, H-460 and Hep G2 cells by MTT assay.Figure optionsDownload high-quality image (99 K)Download as PowerPoint slide