کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538923 | 1122159 | 2011 | 6 صفحه PDF | دانلود رایگان |
Chelerythrine (CHE), a quaternary benzo[c]phenanthridine alkaloid, which is an agent in traditional Chinese medicine exhibits a wide spectrum of pharmacological effects. In this study, we examined the anti-inflammatory activities and mechanism of CHE in vivo and in vitro, respectively. Further, in the analgesic test, CHE also showed pronounced inhibition of the acetic acid-induced writhing response. These results clearly suggested that CHE is a bioactive agent which has a significant anti-inflammatory action, which may be relevant to the inhibition of the release/production of exudates and prostaglandin E2 mediated through cyclooxygenase-2 regulation.
Graphical AbstractChelerythrine was a bioactive agent having significant anti-inflammatory action, which may have relevance to the inhibition of release of exudate/production and PGE2 mediated through COX-2 regulation.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 620–625