کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538966 | 1122160 | 2012 | 7 صفحه PDF | دانلود رایگان |
From the MeOH extract of Sideritis trojana, a new iridoid glycoside, 10-O-(E)-feruloylmelittoside (1) was obtained in addition to four known iridoid glycosides [melittoside (2), 10-O-(E)-p-coumaroylmelittoside (3), stachysosides E (4) and G (5)]. Moreover, five phenylethanoid glycosides [verbascoside (6), isoacteoside (7), lamalboside (8), leonoside A (9), isolavandulifolioside (10), three flavone glycosides (isoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1 → 2)]-β-glucopyranoside (11), 4′-O-methyisoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1 → 2)]-β-glucopyranoside (12), 3′-hydroxy-4′-O-methyisoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1 → 2)]-β-glucopyranoside (13) and a benzylalcohol derivative (di-O-methylcrenatin) were obtained and identified. The structures were elucidated on the basis of NMR and HRMS data. All compounds were tested for their antioxidant activity by in vitro TEAC assay and some of them exhibited moderate activity (0.97–1.44 mM) when compared with the reference compound (quercetin 1.86 mM). Glycosides 6–13, the most active compounds in the TEAC assay, were also tested by flow cytometry to evaluate their ability to affect the levels of reactive oxygen species (ROS) in human prostate cancer cells (PC3).
From Sideritis trojana, a new iridoid glycoside, 10-O-(E)-feruloylmelittoside (1) was isolated in addition to 13 known secondary metabolites. The antioxidant activities of the isolates were evaluated by in vitro TEAC assay.Figure optionsDownload high-quality image (52 K)Download as PowerPoint slide
Journal: Fitoterapia - Volume 83, Issue 1, January 2012, Pages 130–136