Antifungal properties of methanol extract and its active compounds from Brickellia rosmarinifolia Vent

A new isocoumarin, 7-hydroxyl-4-methyl isocoumarine (1), together with three known monoterpenes, (3R, 4R, 6S)-3, 6-dihydroxy-1-menthene (2), (+)-(1R, 3S, 4R, 6S)-6-hydroxymenthol (3) and 4-isopropyl-1-methylcyclohex-2-ene-1, 6-diol (4), was isolated from the methanol extract of Brickellia rosmarinifolia. The structures were determined by spectroscopic means. Compounds 1, 2, 3 and 4 showed antifungal activities against Colletotrichum musae and Peronophythora litchii in vitro.

Graphical AbstractA new isocoumarin, 7-hydroxyl-4-methyl isocoumarine (1) was isolated from the methanol extract of Brickellia rosmarinifolia. The structures were determined by spectroscopic means. It showed antifungal activitiy against Colletotrichum musae and Peronophythora litchii in vitro.Figure optionsDownload as PowerPoint slide