کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2540588 1122600 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IL-25 regulates the polarization of macrophages and attenuates obliterative bronchiolitis in murine trachea transplantation models
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IL-25 regulates the polarization of macrophages and attenuates obliterative bronchiolitis in murine trachea transplantation models
چکیده انگلیسی


• IL-25 deficiency promoted the polarization of M1 macrophages in orthotopic and heterotopic allografts.
• IL-25 inhibited the polarization and pro-inflammatory cytokines productions of M1 macrophages while contribute to the function of M2 macrophages in vitro.

Obliterative bronchiolitis (OB) remains the major limitations for the long-term survival of allografts after lung transplantation. Th17 cells and IL-17 have been recognized as mediators of the development of OB in both animal models and human beings. IL-25, also called IL-17E, is the only anti-inflammatory cytokine of the IL-17 family, capable of regulating Th17 cells function in autoimmune inflammations. Whether IL-25 affects Th17 cells responses and the development of OB remains poorly understood. Acute rejection (AR) of the lung allograft has been regarded as the main problem for the development of OB, in which infiltrations of monocytes/macrophages play important roles. This study explored the potential role of IL-25 in regulation of macrophages polarization and inhibition of IL-17 production in the progression of OB. Here, we showed that IL-25 directly suppressed the expression of inflammatory cytokines, such as IL-6, IL-23, TNF-α, and IL-1β in LPS-induced pro-inflammatory M1 macrophages in vitro. In vivo data demonstrated that IL-25 deficiency promoted the polarization and function of M1 macrophages and aggravated the progression of OB in murine models of both orthotopic and heterotopic trachea transplantation. In conclusion, these data indicated that IL-25 attenuated OB by suppressing the function of M1 macrophages and IL-17 expression, providing an alternative strategy to intervene the development of OB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 25, Issue 2, April 2015, Pages 383–392
نویسندگان
, , , , , , , , , ,