کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2540813 1122611 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice
چکیده انگلیسی


• Zingerone inhibited proinflammatory cytokine expression induced by LPS in vitro.
• Zingerone attenuated pulmonary inflammation by block of MAPKs and NF-κB pathways in LPS-induced ALI model.
• Zingerone attenuated pulmonary edema in LPS-induced murine acute lung injury model.

Zingerone, one of the active components of ginger, is a phenolic alkanone with antioxidant and anti-inflammatory properties. In the present study, we analyzed the role of zingerone against RAW 264.7 cells and acute lung injury induced by lipopolysaccharide (LPS) in mice. RAW cells or BALB/c mice were pretreated with zingerone one hour before stimulated with LPS. We found that zingerone significantly inhibited the production of LPS-induced proinflammatory cytokines in vitro and in vivo. When pretreated with zingerone, pulmonary histopathologic changes, as well as alveolar hemorrhage and neutrophil infiltration were substantially suppressed in lung tissues, with evidence of reduced myeloperoxidase (MPO) activity in murine acute lung injury model. The lung wet-to-dry weight (W/D) ratios, as the index of pulmonary edema, were markedly decreased by zingerone pretreatment. Furthermore, we demonstrated that zingerone attenuates the mitogen-activated protein kinases (MAPK) and nuclear factor-kappaB (NF-κB) signaling pathways through blocking the phosphorylation of ERK, p38/MAPK and IκBα, NF-κB/P65. These results suggest that zingerone may provide protective effects against LPS-induced ALI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 19, Issue 1, March 2014, Pages 103–109
نویسندگان
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