کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2541021 1122630 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dermal γδ T cells — A new player in the pathogenesis of psoriasis
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Dermal γδ T cells — A new player in the pathogenesis of psoriasis
چکیده انگلیسی

Psoriasis is considered as a T-cell driven chronic inflammatory skin disease. Both T helper (Th) 1 and Th17 cells have been demonstrated to participate in psoriasis pathogenesis. Recently, a new subset of γδ T cells residing in the dermis has been identified. Dermal γδ T cells are the major source of interleukin (IL)-17 in the skin upon IL-23 stimulation. More importantly, they are also shown to be involved in psoriasis development. In this review, we focus on this newly discovered cell population both in mice and human, particularly discussing its role in the pathogenesis of psoriasis. The biologic therapeutics targeting dermal γδ T cell and its related molecules in the treatment of psoriasis are also included.


► Outline the characteristics of human and mouse dermal γδ T cells
► Discuss the role of dermal γδ T cells in psoriasis development
► Discuss biologic therapeutics targeting dermal γδ T cell and its related molecules for psoriasis treatment

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 16, Issue 3, July 2013, Pages 388–391
نویسندگان
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