Regulatory role of resveratrol on Th17 in autoimmune disease

The immune system is balanced with cells that respond to microbes by developing into effector cells and cells that regulate the activity of effector cells. In many immune responses a subset of effector T cells termed Th17 are necessary for complete immunity because the cytokine IL-17 that they produce is critical to elimination of the pathogen. However, the activity of Th17 must be balance with development of regulatory T cells termed Tregs. Usually, when the activity of the effector cells is excessive and not balanced by regulatory cells of the immune system, there is the increased risk for development of autoimmune diseases. Therefore in many autoimmune diseases the activity of Th17 exceeds that of Tregs. Therapeutics for treatment of autoimmune diseases such as Multiple Sclerosis (MS) have focused upon immunosuppression, immunomodulation, or even immunoablation of effector cells such as Th17 followed by hematopoietic stem cell transplantation. Very few approaches have attempted to therapeutically increase immune regulatory cells such as Tregs in the treatment of autoimmune disease. This review will focus upon the potential `or the use of resveratrol, a natural plant compound that has already been shown to be a potent anti-inflammatory compound, as a complementary therapeutic for MS that increases the activity of Tregs even though it also increases development of Th17.

Research highlights
► Oral Resveratrol promotes expression of Foxp3 during EAE.
► Oral Resveratrol leads to increased expression of T cell IL-10 during EAE.
► Estrogen and aryl hydrocarbon receptors may underlie resveratrol's rise in Tregs.