کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2541368 1122653 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia
چکیده انگلیسی

Microglial activation has been implicated in many neurological disorders for its inflammatory and/or neurotrophic effects. In this study, we investigated the effects upon activated microglia of Oridonin (Ori), an effective component isolated from Rabdosia rubescens. We pretreated rat primary microglia with or without Ori, then stimulated with lipopolysaccharide (LPS). We found that Ori pretreatment inhibited the release of proinflammatory mediators including nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1 β (IL-1β) and interleukin-6 (IL-6). Such suppressive effects were accompanied by inhibition of DNA binding activity of the critical transcription factor nuclear factor-kappa B (NF-κB). In addition, Ori upregulated the production of the neurotrophic factor, nerve growth factor (NGF). Our findings suggest that Ori may have anti-inflammatory and neuroregulatory effects through modulation of multiple functions of microglia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 9, Issue 3, March 2009, Pages 360–365
نویسندگان
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