Skin regeneration with bone marrow-derived cell populations

Bone marrow-derived cells of distinct differentiation level could differently influence the process of skin regeneration. The results of our study revealed that hematopoietic stem cells (HSC) population influenced the repair of injured tissue slower in comparison with lineage negative (lin−) cell population containing not only HSC but also cell progenitors of different differentiation levels. Wound healing process was faster in lin− cell suspension treated group, the stage of proliferation was more intensive and increased number of skin appendages occurred. The adaptation of purified HSC at the site of injury was longer and the stages of wound healing took place later. The results obtained show that in further experiments the complex procedure of HSC isolation and purification could be shortened and heavy skin injuries could be successfully treated with the help of lin− cell population.

Research Highlights
► Lin– cell population inhibits the inflammation stage of wound healing.
► Lin– cell population stimulate the proliferation stage of wound healing.
► Lin– cell population influence injured skin re-epithelisation.