کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2541660 | 1122669 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Critical timing, location and duration of glucocorticoid administration rescue mice from superantigen-induced shock and attenuate lung injury Critical timing, location and duration of glucocorticoid administration rescue mice from superantigen-induced shock and attenuate lung injury](/preview/png/2541660.png)
Bacterial superantigens, such as staphylococcal enterotoxin B (SEB), are major virulence factors implicated in the pathogenesis of toxic shock. In this study we investigated the efficacy of glucocorticoid therapy in preventing SEB-induced lethal shock initiated through the respiratory route in mice. Dexamethasone, a potent anti-inflammatory steroid, administrated intranasally on the first day, followed by intraperitoneal doses on the subsequent 4 days, was effective in attenuating SEB-induced hypothermia, and reduction in systemic and pulmonary proinflammatory mediator release. This optimal dosing and schedule of glucocorticoid treatment mitigated lung inflammation and resulted in 100% survival in this intranasal mouse model of SEB-mediated shock.
Journal: International Immunopharmacology - Volume 9, Issue 10, September 2009, Pages 1168–1174