کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2541662 1122669 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunosuppressive effect of angiotensin receptor blocker on stimulation of mice CTLs by angiotensin II
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunosuppressive effect of angiotensin receptor blocker on stimulation of mice CTLs by angiotensin II
چکیده انگلیسی

While angiotensin II, which is produced by the renin–angiotensin–aldosterone system, is considered to be the major regulator molecule that controls both the blood pressure and fluid system, there is an increasing body of evidence that this bioactive peptide and its receptor might also contribute to the immune system. However, there are few details known about the direct effect that angiotensin type I receptors (AT1R) have on the cytotoxic T cell (CTL). To clarify the relationship between angiotensin II and its CTL receptor, we used murine splenic and antigen-specific CTLs. Murine CTLs constantly expressed AT1R, with the activation of the AT1R expression strengthened by both anti-CD3 Ab and the use of an antigen-specific methodology. Moreover, the production of IFN-γ and TNF-α through CTL stimulation can be inhibited by the selective AT1R inhibitor, Losartan. In particular, the TNF-α production from activated CTL that had been magnified by angiotensin II, was nullified by the AT1R inhibitor. However, a cytotoxic assay indicated it did not have any effect on the cognate interaction of the CTLs. In addition, the antigen-specific CTL induction by immunization with the CTL antigenic peptide was reduced by angiotensin II type 1 receptor blocker (ARB) in vivo. These findings suggest that ARBs might have the ability to suppress excessive antigen-specific activation and induction of CTLs promoted by angiotensin II.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 9, Issue 10, September 2009, Pages 1183–1188
نویسندگان
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