کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2541844 | 1122677 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma](/preview/png/2541844.png)
Asthma is characterized by difficulty in breathing because of the constriction of the smooth muscles of the bronchi, as a result of inflammation. In the present study, we focus on the protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine allergic model, and assess cytokine release, eosinophilia, and mucus hypersecretion. Allantoin treatment led to significant reduction in the levels of Ig(immunoglobulin)E and T-helper-2-type cytokines, such as IL(interleukin)-4 and IL-5, in bronchoalveolar lavage (BAL) fluid. Airway inflammatory-cell infiltration was remarkably alleviated in allantoin-treated asthma groups, compared with the control group. Moreover, allantoin-treated asthma groups exhibited a marked decrease in cytokine mRNA expression in lung tissues, compared with the control group. The effectiveness of allantoin was similar to that of montelukast, used as a positive control. These results support the utility of allantoin as a protective agent against asthma.
Journal: International Immunopharmacology - Volume 10, Issue 4, April 2010, Pages 474–480