کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2541883 | 1559764 | 2009 | 7 صفحه PDF | دانلود رایگان |
Immunotherapy with Interferon-beta (IFNβ) results in remarkably beneficial effects in patients with relapsing-remitting multiple sclerosis (MS), although the mechanisms by which it exerts these beneficial effects remain poorly understood. An investigation was made of the effects of IFNβ on pro-inflammatory and anti-inflammatory cytokine production in peripheral blood cells in MS patients, both untreated and those undergoing immunotherapy, as well as in healthy controls.Results show a significant increase in the production of pro-inflammatory cytokines such as TNFα, IFNγ and IL-12 in the plasma and in the supernatant of leukocyte cultures from MS patients with the untreated disease; IFNβ administration significantly reduced the levels of TNFα and IFNγ, with no changes in the level of IL-12. The Interferon-beta therapy also led to a significant increase in the production of IL-10, as well as a slight increase in that of TGFβ.The reduction in pro-inflammatory cytokine production in the treated MS patient group, accompanied by a simultaneous increase in the production of anti-inflammatory cytokines and the reduction of relapse rates suggests that the beneficial effects of IFNβ immunotherapy result, at least in part, from the modulation of cytokine patterns.
Journal: International Immunopharmacology - Volume 9, Issues 7–8, July 2009, Pages 824–830