کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2542249 1122694 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages
چکیده انگلیسی

Macrophages are the main cells responsible for the innate immunity, and their activation by lipopolysaccharide (LPS) from Gram-negative bacteria or interferon (IFN)-γ from host immune cells is important for controlling infections. However, the overwhelming activation of macrophages can cause a severe inflammatory state. This study investigated the inhibitory mechanism of xanthohumol (XN) against the inflammatory effectors (IL-1β, TNF-α, and iNOS) in activated RAW264.7 macrophages by using different stimuli such as LPS, IFN-γ, or LPS plus IFN-γ. XN is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. XN reduced the expression of the LPS receptor components such as TLR4 and MD2 resulting in the suppression of NF-κB activation in LPS-activated RAW264.7 cells. In the IFN-γ stimulated RAW264.7 cells, the binding activity of STAT-1α and IRF-1 was inhibited by XN. This suggests that differential signaling pathways are used by XN for the inhibition of excess inflammatory mediators depending on the stimuli in macrophages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 8, Issue 4, April 2008, Pages 567–573
نویسندگان
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