کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2542559 1122710 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats
چکیده انگلیسی

Astragalus membranaceus (AM) has been widely used for treating kidney diseases in traditional Chinese medicine. In this study, the Astragalus polysaccharide (APS), the main active ingredient was isolated and purified from the Rhizomes of AM, which consisted of d-glucopyranose and had the molecular weight of 3.6 × 104 Da. The effect of APS on glomerulonephritis rats induced by cationic Bovine Serum Albumin(C-BSA) was evaluated by flow cytometry using Nuclear Transcription Factor-κB (NF-κB) as marker. Interleukin-2 (IL-2), Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) were determined by the ELISA method. The rats (model group and treatment group) were injected subcutaneously with C-BSA plus incomplete Freund's adjuvant on day 0, C-BSA was injected through the caudal vein from week 2 to week 7 to induce glomerulonephritis. The rats (treatment group) were given APS by intraperitoneal injection from week 2 to week 7. The expression of NF-κB and the concentration of IL-2, IL-6 and TNF-α were significantly decreased in the treatment group. This study clearly suggests that APS is effective in protecting against glomerulonephritis induced by C-BSA through the inhibition of NF-κB mediated-cytokine pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 7, Issue 1, January 2007, Pages 23–28
نویسندگان
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