کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2542653 | 1122719 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
EPS-1 is a novel extracellular polysaccharide produced by a strain of thermotolerant Bacillus licheniformis, isolated from a shallow marine hot spring of Vulcano Island (Italy). In this paper, antiviral and immunomodulatory effects of EPS-1 were evaluated. It was found that EPS-1 treatment impaired HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells.Since several cytokines modulate the immune response to viruses, Th1- and Th2-type cytokines were assayed in supernatants of PBMC in different experimental conditions.EPS-1 induced IL-12, IFN-γ, IFN-α, TNF-α and IL-18, but not IL-4. Thus, the antiviral effect of EPS-1 on PBMC seems to be related to the pattern of cytokines induced.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 6, Issue 1, January 2006, Pages 8–13
Journal: International Immunopharmacology - Volume 6, Issue 1, January 2006, Pages 8–13
نویسندگان
Adriana Arena, Teresa L. Maugeri, Bernadette Pavone, Daniela Iannello, Concetta Gugliandolo, Giuseppe Bisignano,