کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545576 1123964 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation into the anti-thrombosis effect and contents of total saponins and flavonoids in the bioactive fraction of Naodesheng prescription
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Investigation into the anti-thrombosis effect and contents of total saponins and flavonoids in the bioactive fraction of Naodesheng prescription
چکیده انگلیسی

Ethnopharmacological relevanceNaodesheng prescription is a widely used traditional Chinese medicine (TCM), and mainly applied in clinics to treat cerebral arteriosclerosis, ischemic stroke, sequelae of cerebral hemorrhage etc.Aim of the studyThe present study was designed to investigate the anti-thrombosis effects of this prescription, and to search its bioactive fraction.Materials and methodsWe evaluated the anti-thrombotic effects by measuring platelet aggregation in rats, and the clotting time and protection rate in mice. The contents of total saponins and flavonoids in the bioactive fraction were determined by UV–vis spectrophotometry.ResultsThe results showed that Naodesheng has significant anti-thrombotic and anticoagulation effects. The contents of total saponins and flavonoids in the bioactive fraction were 7.885% and 8.434%, respectively.ConclusionsSuch study will contribute to further exploration of Naodesheng in the therapy of thrombosis diseases and to its re-development based on the bioactive fraction and ingredients.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 144, Issue 1, 31 October 2012, Pages 208–212
نویسندگان
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