کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545577 1123964 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Venom's antinociceptive property in the primitive ant Dinoponera quadriceps
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Venom's antinociceptive property in the primitive ant Dinoponera quadriceps
چکیده انگلیسی

Ethnopharmacological relevanceIn northeastern Brazil, Dinoponera (Ponerinae) ants macerate are used to treat ear ache and its sting, rheumatism, and back pain. Such a popular use is a relevant fact that called for experimental evaluation of the antinociceptive activity of Dinoponera venom.Materials and methodsDinoponera quadriceps venom (DqV; 5–500 μg/kg; i.v.) or morphine (3.4 mg/kg; s.c.) were evaluated in mice models of nociception (n=8 animals/group). Negative controls received sterile saline (0.9% NaCl; i.v.).ResultsDqV showed 64% protein content and exhibited antinociceptive activity, without affecting motor function, in the tests: formalin (72%), writhing (52%), von Frey (71%) and hot plate (45%). The antinociceptive activity was abolished under protein denaturant conditions.ConclusionsThis study provided the first demonstration of the antinociceptive property of Dinoponera quadriceps venom in mice models of chemical, mechanical and thermal nociception, corroborating the popular use and suggesting its potential therapeutic utilization in painful conditions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 144, Issue 1, 31 October 2012, Pages 213–216
نویسندگان
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